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Moreover, overly high NO production in the brain can form peroxynitrite , a potent oxidant that damages neurons and has been implicated in neurodegenerative diseases

Hepatocyte Nuclear Factor 4 alpha (HNF4) stands as a pivotal transcription factor within the nuclear receptor superfamily, which represents critical molecular targets for approximately 13% of FDA-approved drugs [2, 3]

However, the beneficial effects of modafinil have been primarily observed in mice, and further clinical studies are necessary to validate its efficacy and safety in humans ( Immunotherapy strategies, such as MHC/neuroantigen peptide constructs, have emerged as experimental approaches for treating METH-induced learning and memory deficits

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